What does O mean?
Ounce (of drugs)
Other definitions of O:
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Surprised
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Zero
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How to use the term O:
Twenty O One "2001"
More slang terms:

IDKWYM
I don't know what you mean

PAP
Post a picture - most commonly used on social media.

IAT
I am tired

SOFS
same old f**king s**t