What does OTP mean?
One True Pairing - a strong preference for two fictional characters to be portrayed together, romantically or otherwise.
Other definitions of OTP:
If you ask someone what they are doing, and they say 'otp', that means 'On The Phone'.
One True Parrot
over the phone
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How to use the term OTP:
"Miss Piggy is Kermit the Frog's OTP."
"i'm talking 2 some one otp"