What does ISC mean?

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ISC:
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More slang terms:

Upper-decker
An act of defecation within the water tank rather than the toilet bowl as a prank or act of vandalism.

10 Toes Down
To remain steadfast, loyal, or committed, especially through challenges or adversity.

Catching Strays
Being inadvertently criticized or insulted when not directly involved or targeted.

Dudette
A colloquial term for a woman or girl, typically used informally.

FRFR
"For real" twice. A colloquial slang abbreviation meaning truly, honestly, or seriously.

Mewing
An exercise involving pressing the tongue flat against the roof of the mouth to reshape the jawline.

Ma Boi
An affectionate slang phrase used to address or refer to a close male friend or companion.

Opps
Enemies or rivals, particularly in street culture or rap beef.

Dump Truck
A notably large and shapely buttocks, usually referring to someone with an exceptional rear end.

BBL
"Brazilian Butt Lift," a cosmetic surgery procedure involving fat transfer to buttocks for enhanced curves.

Bop
A song that is exceptionally catchy or enjoyable.